Citazioni su adulatori, citazioni sui leccapiedi, citazioni sui lecchini, citazioni sui lustrascarpe. Truncal vagotomy (TV) also significantly increased the slope of the volume–pressure curve compared with control, reaching 16.8 ± 1.9 cmH2O when the stomach was distended with 6 ml of saline (F at 104.5; d.f, 1,48; P < 0.0001, ANOVA) (Fig. AKUPUNKTUR UND FUNKTIONELLE DYSPEPSIE — MECHANISMEN, EFFEKTE, STUDIENDESIGNAcupuncture and Functional Dyspepsia — Mechanisms, Effects, Study Design. This repository is populated with tens of thousands of assets and should be your first stop for asset selection. Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance. Additional capsaicin was applied perivagally every 5 min. After washing the gastric contents, a cannula and a pressure transducer were inserted into the stomach through the pylorus. Questa pagina è stata modificata per l'ultima volta il 8 mag 2017 alle 10:40. Please check your email for instructions on resetting your password. Means ±s.e.m., n= 4. in vivo Effects of tetrodotoxin (◆, TTX; A) and truncal vagotomy (•, TV; B) on the intragastric pressure increase evoked by gastric distension of the stomach of intact rats in vivo. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. Join Facebook to connect with Ascanio Lecchini and others you may know. This suggests that nicotinic synapses and the intramural NO pathway in the gastric myenteric plexus are involved in the mediation of gastric relaxation following chronic vagotomy. The stomach was inflated with saline (6 ml) at the rate of 1 ml min−1 and the intraluminal pressure was recorded with and without the pretreatment of TTX (10−7M), hexamethonium (10−4M) or l‐NAME (10−4M). Abnormally low accommodation rate in patients with functional dyspepsia. Scandinavian Journal of Gastroenterology. Learn about our remote access options, Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA, Author's email address: Il variegato fronte di opposizione o di ostilit The coeliac artery was identified and the abdominal aorta was ligated just above the branching of the coeliac artery; a cannula was inserted into the coeliac artery. Presento una raccolta di frasi, citazioni e aforismi sulla presunzione e i presuntuosi. To investigate whether the vagal nerve and splanchnic nerve are involved in the mediation of the accommodation reflex, we performed in vivo experiments using male Sprague—Dawley rats, weighing 225–250 g. These rats were fasted for 12–16 h and anaesthetized by an intramuscular injection of xylazine and ketamine (13 and 87 mg (kg body wt)−1 respectively). expression in specific brain nuclei via 5-HT3 receptors in conscious rats Recently we showed that vagal stimulation evoked the maximum NO release at 2.5 Hz (Takahashi & Owyang, 1995). This suggests that an intramural pathway does not mediate gastric relaxation in an extrinsically denervated stomach. Similar to our results, they showed that intramural neural pathways are not involved in mediating LES relaxation (Price et al. Evviva coloro che si vantano di essere giornalisti ma sono semplicemente dei lecchini di potere. ATP Learn more. In our laboratory we demonstrated that perivagal capsaicin treatment markedly reduced the labelling of neurons in the nodose ganglia if the dye was applied to the mucosa but it had little effect on the labelling if the dye was injected into the serosa and/or muscle layer (Wang, Li & Owyang, 1994). In these rats, the intraluminal‐pressure increase evoked by gastric distension was not affected by TTX (data not shown), indicating the loss of naturally mediated gastric relaxation. The effects of hexamethonium on the pressure increase evoked by gastric distension were less than those of TTX and TV. VIP antiserum also abolishes exogenously applied VIP (100 pmol)‐induced rekxation (Bojo, Lefebvre, NeUgard & Cassuto, 1993). Administration of rabbit VIP antiserum also had no effect on the accommodation reflex in rats with a chronic vagotomy (i.e. It has been demonstrated that the vago–vagal reflex plays an important role in mediating gastric relaxation during food intake (Wilbur & Kelly, 1973; Andrews et al. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. A genetic approach for investigating vagal sensory roles in regulation of gastrointestinal function and food intake. Working off-campus? 1990). Mart. 10.1146/annurev.physiol.68.040504.094635. Non abbiamo pubblicato la notizia per la sua scarsa attendibilità. In the present study, neither rabbit VIP antiserum nor atropine affected the pressure increase induced by gastric distension. We recently demonstrated that the preganglionic fibres in the vagal trunk are connected via nicotinic synapses to at least three types of postganglionic neurons that contain acetylcholine, NO, and VIP and serve as neurotransmitters to mediate gastric contraction and different relaxation modes in the rat stomach (Takahashi & Owyang, 1995). Presento una raccolta di frasi, citazioni e aforismi sull’adulazione. A similar method demonstrated that perivagal capsaicin treatment significantly reduced pancreatic enzyme secretion stimulated by physiological doses of CCK infusion (Li & Owyang, 1993). 1979). These observations confirmed that vagal stimulation of NO release from the gastric myenteric plexus is mediated by nicotinic synapses. Pretreatment with tetrodotoxin (TTX) caused a significant pressure increase by gastric distension, reaching 17.0 ± 1.7 cm H 2 O, suggesting mediation by neural pathways. Mechanism of hyperphagia contributing to obesity in brain-derived neurotrophic factor knockout mice. The following drugs were used: L‐arginine, atropine, capsaicin, guanethidine, hexamethonium, phentolamine, propranolol, and tetrodotoxin (Sigma), l‐NAME (Research Biochemicals Incorporated, Natick, MA, USA), and VIP antiserum (Peninsula, Belmont, CA, USA). ), PC 350, Millar Instruments, Houston, TX, USA) was inserted into the rat stomach through the pylorus to record intragastric pressure. Guarda il profilo completo su LinkedIn e scopri i collegamenti di Michele e le offerte di lavoro presso aziende simili. Laparoscopic Sleeve Gastrectomy—Volume and Pressure Assessment. VIP immunoreactivity is present in the intrinsic neurons of the stomach (Larsson, Fahrenkrug, Schaffalitzky, Sundler, Hakanson & Rehfeld, 1976). Ci fa piacere che qualche gestore riesca ancora a trovare spazio sul mercato agendo semplicemente sui fondamentali del servizio. At 2 and 4 weeks after the truncal vagotomy, the stomach was distended with 6 ml of saline and the intraluminal pressure was recorded in the presence and absence of various antagonists. Gastric distension (6 ml) evoked an increase of 9.0 ± 1.0 cm H2O of intragastric pressure in vivo. Acute hyperglycemia is related to gastrointestinal symptoms in motion sickness: An experimental study. Tra i temi correlati si vedano Frasi, citazioni e aforismi sull’orgoglio, Frasi, citazioni e aforismi su narcisismo, egocentrismo e vanità e Frasi, citazioni e aforismi sull’umiltà.. Frasi, citazioni e aforismi sulla presunzione e i presuntuosi These observations support the concept that VIP is an inhibitory NANC transmitter. Brainstem pathways responsible for oesophageal control of gastric motility and tone in the rat. Dettagli di Topal Lecchini Hülya a Zürich (Indirizzo, Numero di telefono, E-mail, Fax, Homepage) Glutaminergic vagal afferents may mediate both retching and gastric adaptive relaxation in dogs. In perivagal capsaicin‐treated rats the pressure increase evoked by gastric distension (6ml) was 9.1 ± 1.2 cmH2O. Effects of brain stem cholecystokinin-8s on gastric tone and esophageal-gastric reflex. Wistar Kyoto rats have impaired gastric accommodation compared to Sprague Dawley rats due to increased gastric vagal cholinergic tone. This suggests that the vagal sensory pathway mediating the accommodation reflex does not involve capsaic insensitive afferent fibres in intact rats. We hypothesize that adaptive changes may occur after chronic vagotomy to mediate gastric relaxation. Spinal afferents transmit signals of noxious events; vagal fibres monitor peristalsis and trigger secondary peristalsis. Esophageal-gastric relaxation reflex in rat: dual control of peripheral nitrergic and cholinergic transmission. Neurological Aspects of Spinal Cord Injury. Journal of Histochemistry & Cytochemistry. Spatial organization of neurons in the dorsal motor nucleus of the vagus synapsing with intragastric cholinergic and nitric oxide/VIP neurons in the rat. The rats underwent either a bilateral abdominal truncal vagotomy or a sham operation. It is also suggested that the adaptive mechanism mediating the accommodation reflex following vagotomy occurs in the gastric myenteric plexus. l‐NAME in vivo Effects of hexamethonium (▵, A) and the nitric oxide biosynthesis inhibitor, l‐NAME; (▴, B)on the intragastric‐pressure increase evoked by gastric distension of the rat stomach in vivo, compared with control (○). Innervation of the Gastrointestinal Tract. The pressure increase evoked by gastric distension was significantly enhanced in vivo by acute truncal vagotomy (TV), hexamethonium (C6), and NG‐nitro‐L‐arginine methyl ester (l‐NAME), but not by vasoactive intestinal polypeptide (VIP) antiserum, guanethidine, or splanchnicotomy. База данных PEIS-V больше не обновляется с 1 июня 2018г. Patrizia Mascarucci, Né mortale né immortale.Vincenzo Cecchini. Impact of Botulinum Neurotoxin Pyloric Injection During Laparoscopic Sleeve Gastrectomy on Postoperative Gastric Leak: a Clinical Randomized Study. The authors are greatly indebted to Marcus Campbell, Lamberto Galang, and Krista Swaninger for their technical assistance. E poi, parliamoci chiaro, il leccaculismo è davvero un dramma comico!». Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging. Compared with the in vivo studies, gastric distension caused a much larger increase in intragastric pressure, reaching 20.3 ± 2.5 cmH2O, when 6 ml of saline was administered to the denervated stomach. In contrast to pretreatment with l‐NAME and hexamethonium, the intraluminal pressure increase evoked by gastric distension was not affected by guanethidine or splanchnicotomy in vivo suggesting that the sympathetic pathway is not involved in the mediation of gastric relaxation following vagotomy. Condividi su: However, 4 weeks after vagotomy, the accommodation reflex was fully restored in vivo. Visualizza il profilo di Giorgio Lecchini Giovannoni su LinkedIn, la più grande comunità professionale al mondo. CLICCA QUI per … Effect of colonic distension on gastric adaptive relaxation in rats: barostatic evaluation using an orally introduced gastric balloon. The Physiological Society | Hodgkin Huxley House | 30 Farringdon Lane | London EC1R 3AW, UK. Two weeks after TV, the intraluminal pressure increase evoked by gastric distension (6 ml) remained high. These afferent receptors transmit sensory information to the central nervous system and play an important role in the vago–vagal reflex. However, in our study, perivagal capsaicin treatment failed to affect the intragastric pressure increase evoked by gastric distension. However, the pressure increase evoked by gastric distension (6 ml) was significantly enhanced by, The pressure increase evoked by gastric distension (6 ml) was significantly enhanced by. This suggests that different neurotransmitters mediate different modes of relaxation (Takahashi & Owyang, 1995). Similar studies were performed with hexamethonium treatment (20 mg (kg body wt)−1 bolus plus 10 mg (kg body wt)−1 h−1 continuous infusion) to determine the role of presynaptic cholinergic neurons in the mediation of the accommodation reflex. The perfusate was maintained at pH 7.4 and 37 °C, bubbled with a mixture of 95% O2‐5%CO2. Il contratto Premium Access del tuo team sta per scadere. Frasi sui colleghi lecchini fos Quando tutto cominciò “sembrava una cosa di pochi mesi, per risolvere un problema tra amici e invece…In una recente intervista concessa alla Gazzetta dello Sport, Fabrizio Corsi ha raccontato le origini del suo trentennale sodalizio con la società azzurra. 1B). As previously demonstrated, vagal efferent pathway utilizes nicotinic receptors to stimulate NO release from the gastric myenteric plexus (Takahashi & Owyang, 1995). Perivagal treatment with capsaicin did not affect the pressure increase evoked by gastric distension. Handbook of Behavior, Food and Nutrition. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, Gastrointestinal, Hepatic and Pancreatic Physiology, I have read and accept the Wiley Online Library Terms and Conditions of Use, Elicitation of reflex vagal relaxation of the stomach from pharynx and oesophagus in the cat, Selective depletion of the acetylcholine and vasoactive intestinal polypeptide of the guinea‐pig myenteric plexus by differential mobilization of distinct transmitter pools, Histochemical localization of nitric oxide synthase in rat enteric nervous system, The role of the vagus and splanchnic nerves in the regulation of intragastric pressure in the ferret, Release of nitric oxide upon stimulation of nonadrenergic noncholinergic nerves in the rat gastric fundus, Involvement of vasoactive intestinal polypeptide in gastric reflex relaxation, Localization of nitric oxide synthase indicating a neural role for nitric oxide, Nitric oxide as an inhibitory non‐adrenergic non‐cholinergic neurotransmitter, Both ATP and the peptide VIP are inhibitory neurotransmitters in guinea‐pig ileum circular muscle, Evidence for dual components in the non‐adrenergic non‐cholinergic relaxation in the rat gastric fundus: role of endogenous nitric oxide and vasoactive intestinal polypeptide, Comparison of the effect of vasoactive intestinal polypeptide and non‐adrenergic non‐cholinergic neuron stimulation in the cat gastric fundus, Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid, Observation of the postural activity of the stomach, Speculations on the structure/function relationship for vagal and splanchnic afferent endings supplying the gastrointestinal tract, Effect of immunization against vasoactive intestinal polypeptide on gastric corpus tone and motility in the ferret, Plasticity in the gastric inhibitory innervation after immunization against VIP and vagotomy in the ferret, Gastric adaptive relaxation and symptoms after vagotomy, Enteric inhibitory neural regulation of human colonic circular muscle: role of nitric oxide, Peripheral sympathetic pathways to gastroduodenal region of the guinea pig, Localization of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons, Influence of vasoactive intestinal polypeptide and, Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion, Pancreatic secretion evoked by cholecystokinin and non‐cholecystokinin‐dependent duodenal stimuli via vagal afferent fibres in the rat, Antagonists of nitric oxide synthesis inhibit nerve‐mediated relaxations of longitudinal muscle in guinea pig ileum, Effect of bilateral cervical vagotomy on balloon‐induced lower esophageal sphincter relaxation in the dog, Perivagal application of capsaicin abolishes the response of vagal gastric mechanoreceptors to cholecystokinin, Reflex decreases in intragastric pressure in response to cholecystokinin in rats, Cholecystokinin inhibits gastric motility and emptying via capsaicin‐sensitive vagal pathway in rats, Effects of the vagus nerves on gastric motility and release of vasoactive intestinal polypeptide in the anaesthetized lamb, Vagal control of gastric motility: participation of nitric oxide and vasoactive intestinal polypeptide in the regulation of gastric relaxation, Neural and humoral factors influence gastric receptive relaxation in dogs, Gastroduodenal mucosal afferent fibers mediate physiological action of cholecystokinin on pancreatic secretion, Effect of proximal gastric, complete gastric, and truncal vagotomy on canine gastric electric activity, motility, and emptying, Corelease of PHI and VIP by vagal stimulation in the dog, Release of endogenous acetylcholine from a vascularly perfused rat stomach.